Dimethyl Sulfoxide
Apexbio Technology LLC GW0742 317318-84-6 10mM (in 1mL DMSO)
GW0742 is a synthetic selective agonist of peroxisome proliferator-activated receptor / (PPAR / ) a ligand-dependent transcription factor involved in regulating lipid metabolism inflammation and energy homeostasis Activation of PPAR / modulates downstream gene transcription influencing physiological processes including inflammatory responses and neuronal protection Experimental studies demonstrate GW0742 s role in attenuating inflammation-mediated tissue injury such as ischemia/reperfusion-induced intestinal damage as well as mitigating radiation-induced neuroinflammation and cognitive impairment in animal models Thus GW0742 serves as a research tool to study PPAR / specific pathways in inflammatory diseases metabolic processes and neuroprotective mechanisms
Apexbio Technology LLC Zafirlukast 107753-78-6 10mM (in 1mL DMSO)
Zafirlukast (CAS 107753-78-6) is an antagonist targeting cysteinyl leukotriene receptors (CysLTR) which mediate inflammatory signaling pathways By competitively inhibiting leukotriene receptor binding it disrupts the leukotriene-driven inflammatory response Zafirlukast demonstrates antagonist potency against leukotriene receptors with an IC50 value of approximately 0 6 M and exhibits moderate inhibitory activity on CYP2C9 enzyme (IC50 of about 7 0 M) In biomedical research Zafirlukast serves as a pharmacological tool for studying leukotriene-mediated inflammation and receptor signaling processes
Apexbio Technology LLC Tinidazole 19387-91-8 10mM (in 1mL DMSO)
Tinidazole is a synthetic nitroimidazole derivative with antiparasitic and antibacterial activity used to study protozoal infections and anaerobic bacterial conditions After cellular uptake it is activated by nitroreductase enzymes forming cytotoxic metabolites that induce DNA strand breaks and inhibit nucleic acid synthesis leading to cell death Tinidazole is commonly used in vitro to evaluate its efficacy against pathogens like Giardia lamblia Trichomonas vaginalis and Entamoeba histolytica IC50 values against Giardia lamblia trophozoites typically range from 0 5 to 5 M making it a useful tool for antiparasitic drug screening and antimicrobial studies
Apexbio Technology LLC Pyrazinamide 98-96-4 10mM (in 1mL DMSO)
Pyrazinamide is an antimycobacterial agent primarily used in the laboratory research of tuberculosis infection As a synthetic pyrazine derivative it acts by targeting mycobacterial fatty acid synthesis pathways and disrupting bacterial membrane energetics thereby exerting bactericidal activity particularly under acidic conditions Pyrazinamide is routinely employed in in vitro cell and bacterial culture studies to investigate mechanisms of tuberculosis pathogenesis drug resistance and potential combination therapies Its inhibitory effect is usually quantified in terms of IC50 values typically ranging from approximately 10 to 60 g/mL depending on experimental conditions and mycobacterial strain types
Medchemexpress LLC Dnl343 Solution 10Mm 1Ml Dmso | HY149555-10MM 1ML DMSO
Dnl343 Solution 10Mm 1Ml Dmso
Medchemexpress LLC Terbufoxon sulfoxide | 56165-57-2 | 1 MG
Terbufoxon sulfoxide (Terbufos oxon sulfoxide) is a metabolite of the insecticide Terbufos found in the pepper leaf matrix. This product is intended for research use only.
- Metabolite of the insecticide Terbufos
- For research use only
- Molecular weight: 288.36
- Formula: C9H21O4PS2
- Shipping: Room temperature (continental US)
- Storage: As per Certificate of Analysis
Apexbio Technology LLC SAR245409 (XL765) 1349796-36-6 10mM (in 1mL DMSO)
SAR245409 (XL765 CAS 1349796-36-6) is a selective dual inhibitor of phosphatidylinositol-3-kinase (PI3K) and mammalian target of rapamycin (mTOR) with high potency against PI3K (IC50 9 nM) It suppresses the PI3K/Akt/mTOR signaling cascade by preventing formation of phosphatidylinositol-3 4 5-triphosphate (PIP3) at the cell membrane and downstream phosphorylation of AKT p70S6 kinase and S6 SAR245409 demonstrates antitumor activity in cancer models exhibiting genetic alterations in PI3K pathways enhancing growth suppression and apoptosis It is commonly employed in preclinical studies evaluating PI3K/mTOR-targeted approaches in cancer therapy
Apexbio Technology LLC SCR7 1533426-72-0 10mM (in 1mL DMSO)
SCR7 (CAS 1533426-72-0) is a small-molecule inhibitor targeting DNA ligase IV and to a lesser extent DNA ligase III It interacts with the DNA-binding domain of DNA ligase IV thereby diminishing its affinity for double-strand breaks (DSBs) and effectively blocking nonhomologous end-joining (NHEJ)-mediated DNA repair In cell culture models expressing inducible Cas9 SCR7-mediated transient inhibition of NHEJ promotes increased homologous-directed repair (HDR) by facilitating accumulation in the S/G2 phase SCR7 treatment in mice transiently impairs lymphocyte development due to the reversible inhibition of DNA ligase IV activity during V(D)J recombination Thus SCR7 serves as a useful tool in genome editing research to enhance precise gene editing efficiency
Apexbio Technology LLC Efavirenz 154598-52-4 10mM (in 1mL DMSO)
Efavirenz is a non-nucleoside reverse transcriptase inhibitor targeting human immunodeficiency virus type-1 (HIV-1) reverse transcriptase (RT) It functions by binding specifically to an allosteric site of HIV-1 RT thereby inhibiting viral RNA-dependent DNA polymerase activity essential for HIV replication Efavirenz exhibits inhibitory activity against wild-type HIV-1 RT with reported IC95 values ranging from approximately 1 5 to 3 nM and retains inhibitory potency against several known NNRTI-resistant RT variants Due to its molecular mechanism and specificity Efavirenz is frequently utilized in antiviral studies particularly HIV research investigating RT inhibition and HIV resistance mechanisms
Apexbio Technology LLC PKI-402 1173204-81-3 10mM (in 1mL DMSO)
PKI-402 (CAS 1173204-81-3) is an ATP-competitive inhibitor targeting class I PI3Ks (PI3K ) with IC50 values of 1 nM 7 nM 16 nM and 14 nM respectively PI3Ks are enzymes central to the PI3K/Akt/mTOR signaling pathway impacting cellular proliferation survival differentiation and migration processes critically involved in cancer progression PKI-402 reduces cell growth and phosphorylation of PI3K/mTOR downstream signaling proteins in human tumor cell lines including breast glioma pancreatic and non-small cell lung cancers In xenograft mouse models (MDA-MB-361) PKI-402 administration suppresses Akt phosphorylation triggers apoptosis (PARP cleavage) and inhibits tumor growth highlighting its significance for cancer biology research
Apexbio Technology LLC Cyclophosphamide 50-18-0 10mM (in 1mL DMSO)
Cyclophosphamide is a nitrogen mustard alkylating prodrug activated via hepatic enzymes to its active metabolites These metabolites alkylate DNA primarily at guanine residues resulting in DNA cross-linking strand breaks and mutations consequently triggering cytotoxic effects Cyclophosphamide exhibits cytotoxicity in vitro with an IC50 of 37 6 M in mouse embryo BALB/c 3T3 cells and an IC50 of 8 79 M against human HL60 cells It impacts immune regulation by decreasing regulatory T cell counts and suppressive marker expression (FoxP3 GITR) facilitating immune response modulation Commonly applied in cancer and immunological research cyclophosphamide is also employed in genotoxicity assays due to its capacity to induce chromosomal aberrations and mutations
Apexbio Technology LLC GSK343 1346704-33-3 10mM (in 1mL DMSO)
GSK343 (CAS 1346704-33-3) is a selective SAM-competitive inhibitor targeting the histone lysine methyltransferase EZH2 which is the catalytic component of polycomb repressive complex 2 (PRC2) responsible for trimethylation of histone H3 at lysine 27 (H3K27me3) By competitively inhibiting EZH2 s methyltransferase activity GSK343 disrupts H3K27me3-mediated transcriptional silencing It shows potent inhibitory activity against EZH2 (IC50 4 nM) moderate inhibition against EZH1 (240 nM) but minimal impact on other SAM-dependent enzymes In vitro studies with various cancer cell models confirm its ability to reduce H3K27 trimethylation limit proliferation induce apoptosis promote autophagy and enhance chemosensitivity highlighting its utility as a research tool to study EZH2-related mechanisms
Apexbio Technology LLC TAK-242 243984-11-4 10mM (in 1mL DMSO)
TAK-242 (CAS 243984-11-4) also known as resatorvid is a cyclohexene derivative that functions as a selective inhibitor of Toll-like receptor 4 (TLR4) signaling Mechanistically TAK-242 binds specifically to the intracellular domain of TLR4 disrupting its interaction with downstream adaptor proteins and thus suppressing activation of inflammatory signal pathways triggered by lipopolysaccharide (LPS) In vitro TAK-242 inhibits LPS-induced production of nitric oxide TNF- and interleukin-6 in macrophages (IC50 1 1 11 nM) Preclinical animal models indicate its potential usefulness in mitigating inflammatory responses associated with neuropsychiatric conditions triggered by stress
Apexbio Technology LLC JNJ-7706621 443797-96-4 10mM (in 1mL DMSO)
JNJ-7706621 (CAS 443797-96-4) is an inhibitor targeting cyclin-dependent kinases (CDKs) and Aurora kinases specifically CDK1 (IC50 0 009 mol/L) CDK2 (0 004 mol/L) CDK3 (0 003 mol/L) CDK4 (0 058 mol/L) CDK6 (0 253 mol/L) Aurora A (0 011 mol/L) and Aurora B (0 015 mol/L) It selectively reduces proliferation of tumor cells relative to normal human cells with approximately 10-fold higher specificity Independent of cellular status of p53 retinoblastoma protein or p-glycoprotein expression JNJ-7706621 induces apoptosis suppresses colony formation and inhibits growth highlighting its utility in cancer research